A New Design of Biosensor Integrating Single-Walled Carbon Nanotubes, Metal-Organic Frameworks, and Chitosan for the Detection of Acute Myeloid Leukemia
DOI:
https://doi.org/10.54097/h7ncsj11Keywords:
Bio-FET Sensor; Acute Myeloid Leukemia; Carbon Nanotube; Metal-Organic Framework; Chitosan; Aptamer.Abstract
Acute myeloid leukemia (AML) is a hazardous blood cancer originating from bone marrow. As most contemporary detection methods, such as bone marrow tests and spectroscopic tests, still fail to achieve either high sensitivity or biocompatibility, a novel diagnosis method is needed. Biosensors are devices that detect targeted biomolecules to generate fast, reliable responses in real-time, making them advantageous for blood cancer diagnosis and the detection of minimal residual disease. As only a few biosensors specifically targeting AML have been published recently, here we propose a novel multiplex BioFET sensor, based on nanomaterials like carbon nanotube, copper-zirconium, and iron-based metal-organic framework, by using modified polymer chitosan and applying three aptamers targeting three different biomarkers, to maximize the sensitivity, selectivity, endurance, and biocompatibility of the detection of AML cells in the blood to provide a theoretical yet pragmatic model. Despite that there are some theoretical advantages, such as multiplexity, biocompatibility, and instantaneousness, the biosensor still faces some potential issues, including cross-talk, medical safety concerns, and production costs, which require extensive further research to address and improve these problems fully.
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