Construction of Injectable Tetra-Polyethylene Glycol Hydrogel Adhesive for Wound Healing
DOI:
https://doi.org/10.54097/0g88kc93Keywords:
Hydrogel, strong tissue adhesion, microstructure, mechanical properties, tissue binder.Abstract
Hydrogel wound dressings are medical materials that accelerate wound healing by maintaining a moist environment, promoting tissue repair, and absorbing exudate. Its core efficacy is based on the material's high-water content (typically 60%-90%) and biocompatibility, which can provide ideal repair conditions for wounds while reducing the risk of complications. In this work, we constructed a class of tetra-polyethylene glycol hydrogel systems based on rapid chemical reactions, with a fast gelation rate, significant mechanical strength, and sufficient adhesion. Cytotoxicity tests demonstrated that the hydrogels had good biocompatibility, the hydrogel adhesives did not cause secondary damage to the surrounding tissues, and could promote tissue repair and regeneration, providing ideas for the development of a new generation of bioadhesives.
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