Synergistic Treatment of Multiple Sclerosis by Ketogenic Diet and Vitamin D
DOI:
https://doi.org/10.54097/y38bzk12Keywords:
Multiple sclerosis (MS), Ketogenic diet, Vitamin D, Single cell RNA-sequencing, Single cell ATAC-sequencing, Oligodendrocytes.Abstract
Multiple sclerosis (MS) is a chronic autoimmune disease in which the immune system mistakenly attacks the myelin sheath, resulting in the demyelination of neurons in the central nervous system (CNS). This damage leads to symptoms such as fatigue, blurred vision, muscle weakness, and cognitive impairment. Globally, about 2.8 million people live with MS, making it a significant neurological burden. Current treatments for MS are difficult to implement because they are expensive, associated with side effects, and vary in availability across countries, which impacts their effectiveness. Nutrition has emerged as an important aspect of MS treatment. Ketogenic diets (KDs), which are low in carbohydrates and high in fats, have been shown to protect the nervous system and reduce inflammation in MS. In addition, low vitamin D levels are recognized as a risk factor for MS. Using single-nucleus and single-cell RNA sequencing analyses, together with oligodendrocyte cell line experiments, this study provides evidence that vitamin D and the KD may act synergistically to prevent MS development. These findings suggest a potential dietary approach to lowering MS risk that is simple to implement and could benefit populations across diverse social and economic conditions.
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